Salbutamol delays human eosinophil apoptosis via a cAMP-dependent mechanismReportar como inadecuado




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* Corresponding author 1 Tampere University Hospital 2 Department of Respiratory Medicine 3 Faculty of Medicine

Abstract : Eosinophils play a major role in asthma. One described mechanism leading to the impaired clearance of these cells from the lung is the delay in their programmed cell death apoptosis. β-adrenoceptor agonists have been shown to prolong survival and delay apoptosis of eosinophils. The aim of the present study was to evaluate the mechanisms, especially the role of cAMP pathway, in the prolongation of human eosinophil survival by a selective β-agonist salbutamol.

keyword : eosinophils apoptosis salbutamol cAMP





Autor: Hannu Kankaanranta - Jouni Parkkonen - Pinja Ilmarinen-Salo - Mark A. Giembycz - Eeva Moilanen -

Fuente: https://hal.archives-ouvertes.fr/



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