Tumor Necrosis Factor-α T-857C rs1799724 Polymorphism and Risk of Cancers: A Meta-AnalysisReportar como inadecuado




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Disease Markers - Volume 2016 2016, Article ID 4580323, 9 pages -

Review Article

Department of Clinical Laboratory and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Received 6 September 2016; Revised 4 December 2016; Accepted 6 December 2016

Academic Editor: Hubertus Himmerich

Copyright © 2016 Ping Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To investigate the potential association of tumor necrosis factor-α T-857C polymorphism with susceptibility to the five common malignant tumors. Materials and Methods. A comprehensive search of PubMed-Medline, Embase, and Web of Science databases was performed up to November 2015. Pooled odds ratios ORs and 95% confidence intervals 95% CIs were calculated to assess the strength of the association. Subgroup analysis, heterogeneity analyses, and publication bias were also texted in the meta-analysis. Results. A total of twenty-two publications involving 5215 cases and 6755 controls were recruited. Overall, the meta-analysis revealed an increased risk between the TNF-α T-857C polymorphism and gastric cancer susceptibility in T versus C model, heterozygote genetic model, and dominant genetic model. An increased risk between the TNF-α T-857C polymorphism and hepatocellular cancer susceptibility in homozygote genetic model and recessive genetic model was also found. No significant association was found between the TNF-α T-857C polymorphism and colorectal cancer, cervical cancer, and prostate cancer. Conclusions. Our meta-analyses suggest that TNF-α T-857C polymorphism may be associated with increased risk of gastric cancer and hepatocellular cancer development. Therefore, the TNF-α T-857C polymorphism could be considered as one possible risk factor of gastric cancer and hepatocellular cancer according to our study.





Autor: Ping Wang, June Wang, Mingxia Yu, and Zhiqiang Li

Fuente: https://www.hindawi.com/



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