Bullous Skin Diseases: Classical Types of Autoimmune DiseasesReportar como inadecuado

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ScientificaVolume 2013 2013, Article ID 457982, 5 pages

Review ArticleLaboratory of Clinical Immunology, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands

Received 31 October 2012; Accepted 12 December 2012

Academic Editors: A. Amedei, G. Lesinski, and U. Tursen

Copyright © 2013 Jan Damoiseaux. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The prototypic bullous skin diseases, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, are characterized by the blister formation in the skin and-or oral mucosa in combination with circulating and deposited autoantibodies reactive with hemidesmosomes. Koch’s postulates, adapted for autoimmune diseases, were applied on these skin diseases. It appears that all adapted Koch’s postulates are fulfilled, and, therefore, these bullous skin diseases are to be considered classical autoimmune diseases within the wide and expanding spectrum of autoimmune diseases.

Autor: Jan Damoiseaux

Fuente: https://www.hindawi.com/


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