Methylchloroisothiazolinone-Methylisothiazolinone and Methylisothiazolinone Sensitivity in HungaryReportar como inadecuado

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Dermatology Research and Practice - Volume 2016 2016, Article ID 4579071, 5 pages -

Clinical StudyDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest 1085, Hungary

Received 3 November 2015; Revised 25 January 2016; Accepted 8 February 2016

Academic Editor: Franz Trautinger

Copyright © 2016 Györgyi Pónyai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Due to allowing of methylisothiazolinone MI in cosmetics, cleaning products, and paints, an epidemic of MI-hypersensitivity emerged. Patch testing Kathon CG® 3:1 mixture of methylchloroisothiazolinone and methylisothiazolinone, MCI-MI does not correctly detect MI contact allergy, due to the low concentration of MI in the test material. Methods. A retrospective survey was performed to estimate the prevalence of MCI-MI hypersensitivity in 14693 patients tested consecutively between 1993 and 2014. Moreover, currently 314 patients were prospectively tested with the allergens MCI-MI and with MI during one year. Results. MCI-MI hypersensitivity increased retrospectively from 0.5% to 6.0%. By current prospective testing we detected 25 patients 8% with MCI-MI and-or MI positive reactions. Out of the 25 patients 10 were only MCI-MI positive, 9 were only MI positive, and 6 were MCI-MI and MI positive. If MI had not been tested separately, MI contact allergy would have missed in 36% of all detected cases and in 2.8% of the total 314 patients. Conclusions. The frequency of MCI-MI hypersensitivity is increasing also in Hungary. We confirm that, in order to detect MI contact allergy, it needs to be tested separately. A further increase of MI hypersensitivity might be expected in the future as products containing MI are still widely available.

Autor: Györgyi Pónyai, Ilona Németh, and Erzsébet Temesvári



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