Sparfloxacin-Metal Complexes as Urease Inhibitors: Their Synthesis, Characterization, Antimicrobial, and Antienzymatic EvaluationReportar como inadecuado




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Journal of ChemistryVolume 2013 2013, Article ID 306385, 12 pages

Research Article

Faculty of Pharmacy, Jinnah University for Women, Karachi 74600, Pakistan

United Biotechnologies, Karach-75270, Pakistan

Dow College of Pharmacy, Dow University of Health Sciences, Karachi 74200, Pakistan

H.E.J Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan

Received 29 May 2013; Revised 10 September 2013; Accepted 15 September 2013

Academic Editor: Stavros Lalas

Copyright © 2013 Somia Gul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Four new metal complexes S12–S15 of SPFX third-generation quinolones via heavy metals have been synthesized in good yield and characterized by physicochemical and spectroscopic methods including TLC, IR, NMR, and elemental analyses. Sparfloxacinato ligand binds with metals through pyridone and oxygen atom of carboxylic group. The biological actives of complexes have been tested against four Gram-positive and seven Gram-negative bacteria and six different fungi. Statistical analysis of antimicrobial data was done by one-way ANOVA, Dunnett’s test; it was observed that S13, S14, and S15 were found to be most active complexes. Antifungal data confirm that all four synthesized complexes are most active and show significant activity against F. solani with respect to parent drug and none of complexes show activity against A. parasiticus, A. effuris, and S. cervicis. To study inhibitory effects of newly formed complexes, enzyme inhibition studies have been conducted against urease, α-chymotrypsin, and carbonic anhydrase. Enzymatic activity results of these complexes indicated them to be good inhibitors of urease enzyme while all complexes show mild activities against carbonic anhydrase enzyme. Further research may prove the promising role of these synthesized complexes as urease inhibitors.





Autor: Somia Gul, Najma Sultana, M. Saeed Arayne, Sana Shamim, Mahwish Akhtar, and Ajmal Khan

Fuente: https://www.hindawi.com/



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