STIM1 and Orai1: novel targets for vascular diseasesReport as inadecuate




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Science China Life Sciences

, Volume 54, Issue 8, pp 780–785

First Online: 24 July 2011Received: 09 May 2011Accepted: 12 June 2011

Abstract

The past five years have witnessed the discovery of the endoplasmic reticulum calcium Ca sensor STIM1 and the plasma membrane Ca channel Orai1 as the bona fide molecular components of the store-operated Ca entry SOCE and the Ca release-activated Ca current ICRAC. It has been known for two decades that SOCE and ICRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking ICRAC. In recent years however, studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions. Here, we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.

Keywordscalcium signaling calcium channels Orai1 STIM1 CRAC channels vascular disease This article is published with open access at Springerlink.com

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Author: Wei Zhang - Mohamed Trebak

Source: https://link.springer.com/article/10.1007/s11427-011-4206-6







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