Physiological roles of NAADP-mediated Ca2 signalingReport as inadecuate

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Science China Life Sciences

, Volume 54, Issue 8, pp 725–732

First Online: 24 July 2011Received: 15 June 2011Accepted: 25 June 2011


Nicotinic acid dinucleotide phosphate NAADP is unique amongst Ca mobilizing messengers in that its principal function is to mobilize Ca from acidic organelles. Early studies indicated that it was likely that NAADP activates a novel Ca release channel distinct from the well characterized Ca release channels on the sarco-endoplasmic reticulum ER, inositol trisphosphate and ryanodine receptors. In this review, we discuss the emergence of a novel family of endolysosomal channels, the two-pore channels TPCs, as likely targets for NAADP, and how molecular and pharmacological manipulation of these channels is enhancing our understanding of the physiological roles of NAADP as an intracellular Ca mobilizing messenger.

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Author: Antony Galione - John Parrington - Tim Funnell


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