Increased Expression of TRPS1 Affects Tumor Progression and Correlates with Patients Prognosis of Colon CancerReportar como inadecuado




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BioMed Research InternationalVolume 2013 2013, Article ID 454085, 6 pages

Research Article

Department of General Surgery, Shanghai Putuo District Center Hospital, Shanghai 200062, China

Department of General Surgery, Shanghai Zhabei District Shibei Hospital, Shanghai 200435, China

Department of General Surgery, Shanghai Eighth People-s Hospital, Shanghai 200235, China

Received 9 March 2013; Revised 8 May 2013; Accepted 9 May 2013

Academic Editor: Robert A. Vierkant

Copyright © 2013 Jun Hong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To detect the expression pattern of tricho-rhino-phalangeal syndrome-1 TRPS1 in human colon cancer and to analyze its correlation with prognosis of patients with this disease. Methods. The expressions of TRPS1 in human colon cancer and its corresponding noncancerous colon tissues were detected at both mRNA and protein levels. Results. The mRNA and protein expression levels of TRPS1 were both significantly higher in colon cancer than in corresponding noncancerous colon tissues both . The protein level of TRPS1 in colon cancer tissues was significantly correlated with the mRNA level , . Additionally, immunohistochemistry analysis also found increased TRPS1 expression in 63.0% 63-100 of colon cancer tissues. High TRPS1 expression was significantly associated with positive lymph node metastasis and higher pathological stage of patients with colon cancer. Multivariate Cox regression analysis further suggested that the increased expression of TRPS1 was an independent poor prognostic factor for this disease. Conclusion. Our data offer the convincing evidence for the first time that the increased expression of TRPS1 may be involved in the pathogenesis and progression of colon cancer. TRPS1 might be a potential marker to predict the prognosis in colon cancer.





Autor: Jun Hong, Jie Sun, and Tao Huang

Fuente: https://www.hindawi.com/



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