Antibiotic Resistance of Salmonella enterica Serovar Typhi in Kolkata, India, and In Vitro Experiments on Effect of Combined ChemotherapyReportar como inadecuado

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The Scientific World JournalVolume 2012 2012, Article ID 454059, 4 pages

Research Article

Bacteriology and Serology Unit, Department of Microbiology, Calcutta School of Tropical Medicine, C. R. Avenue, Kolkata 700073, India

Department of Zoology, Gour Banga University, NH-34, Mokdumpur, Malda 732103, India

Department of Physiology and Biophysics, KPC Medical College and Hospital, Jadavpur, Kolkata 700032, India

Received 17 October 2011; Accepted 28 December 2011

Academic Editors: Q. He and P. Mastroeni

Copyright © 2012 Shyamapada Mandal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This communication states the changing patterns of Salmonella enterica serovar Typhi S. Typhi isolates causing enteric fever in and around Kolkata, India. Among the isolates resistance to ampicillin A, chloramphenicol C, cotrimoxazole Co and tetracycline T were plasmid mediated; the plasmid was unstable in S. Typhi, and the other enteric bacteria like Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris were found to be the potential source of dissemination of such plasmids into S. Typhi. The infection with such S. Typhi strains were successfully treated with ciprofloxacin Cp: MICs 0.0075–0.075 μg mL

and-or ofloxacin Ofx: MICs 0.0125–0.075 μg mL

, but in the later course, the S. Typhi strains, showing resistance to nalidixic acid, developed low level of resistance to Cp and Ofx, causing the treatment failure. Thus, the treatment regimen was shifted to the third generation cephalosporins like ceftriaxone Ct and cefotaxime Cf. Keeping in mind the anticipation of development of resistance to Ct-Cf, we prepared the treatment regimen for MDR enteric fever, based on the double-drug synergy tests in vitro; Cp-gentamycin FICI 0.121–0.216 and Cp-trimethoprim FICI 0.14–0.483 combinations were found effective against S. Typhi isolates having decreased sensitivity to cp MICs: 0.5–1.25 μg mL


Autor: Shyamapada Mandal, Manisha DebMandal, and Nishith Kumar Pal



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