Recombinant Human Bone Morphogenetic Protein-2 rhBMP-2 for the Treatment of Nonunion of the Femur in Children and Adolescents: A Retrospective AnalysisReportar como inadecuado




Recombinant Human Bone Morphogenetic Protein-2 rhBMP-2 for the Treatment of Nonunion of the Femur in Children and Adolescents: A Retrospective Analysis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BioMed Research International - Volume 2017 2017, Article ID 3046842, 5 pages - https:-doi.org-10.1155-2017-3046842

Research Article

Department of Trauma, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Department of Pediatric Orthopaedic Surgery, Children’s Hospital Hamburg-Altona, Hamburg, Germany

Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Correspondence should be addressed to Alexander S. Spiro

Received 9 January 2017; Accepted 19 February 2017; Published 2 March 2017

Academic Editor: Oliver B. Betz

Copyright © 2017 Tim N. Hissnauer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of this study was to examine clinical and radiographic healing after rhBMP-2 application in children and adolescents presenting with nonunion of the femur and to investigate the safety of rhBMP-2 use in these cases. Materials and Methods. We reviewed the medical records of five patients with a mean age of 11 years 5.4 to 16.2 with nonunion of the femur who were treated with rhBMP-2 and internal fixation using a locking plate at a single institution. Particular attention was paid to identify all adverse events that may be due to rhBMP-2 use. Results. Union occurred in four of five patients at a mean of 12.1 months 7.9 to 18.9. The locking plates were removed after a mean of 16 months 11 to 23. One patient had nonunion due to deep infection. After a mean follow-up of 62.5 months 17 to 100, union was still evident in all four patients and they were fully weight-bearing without pain. Discussion. In this retrospective study, rhBMP-2 combined with a locking plate has been used successfully to treat children and adolescents with nonunion of the femur in four of five cases. One major complication was thought to be possibly related to its use.





Autor: Tim N. Hissnauer, Norbert Stiel, Kornelia Babin, Martin Rupprecht, Karsten Ridderbusch, Johannes M. Rueger, Ralf Stuecker, 

Fuente: https://www.hindawi.com/



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