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BMC Biology

, 8:94

First Online: 19 July 2010Received: 02 June 2010Accepted: 05 July 2010


Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ubiquitination and degradation of droplet-associated proteins. A deficiency of spartin apparently causes lipid droplets to accumulate.

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Electronic supplementary materialThe online version of this article doi:10.1186-1741-7007-8-94 contains supplementary material, which is available to authorized users.

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Autor: Philipp Alberts - Daniela Rotin


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