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International Journal of Chronic Diseases - Volume 2014 2014, Article ID 127426, 5 pages -

Clinical Study

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey

Division of Hematology, Department of Pediatrics, School of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey

Department of Internal Medicine, School of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Ondokuz Mayis University, 55000 Samsun, Turkey

Received 28 November 2013; Revised 2 February 2014; Accepted 5 February 2014; Published 12 March 2014

Academic Editor: Tadeusz Robak

Copyright © 2014 Gozde Yildirim Cetin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this paper we want to demonstrate whether higher than normal levels of RDW, and lower than normal levels of MPV can be used as indicators of subclinical inflammation and tools for treatment decision in FMF or not. The participants in this study included 89 patients with FMF during attack-free periods and 30 healthy controls. The RDW and platelet counts were significantly higher, while the MPV was significantly lower in the patients with FMF group than healthy control group ; ; , resp

In the attack-free FMF group, a negative correlation was found between the MPV and RDW values , . The positive correlation was found between the RDW and ESR , . And the negative correlation was found between the MPV and CRP , . Consequently, our results suggest that low MPV and high RDW levels may provide additional information about subclinical inflammation in FMF patients. But other strong predisposing factors affecting subclinical inflammation in FMF should be considered. Further studies with large numbers of patients are needed. Treatment of FMF should include not only prevention of acute attacks but also decreasing of the subclinical inflammation.





Autor: Gozde Yildirim Cetin, Ozlem Gul, Fatma Kesici-Metin, İrem Gokalp, and Mehmet Sayarlıoglu

Fuente: https://www.hindawi.com/



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