Interaction of Thioamides, Selenoamides, and Amides with DiiodineReport as inadecuate

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Bioinorganic Chemistry and Applications - Volume 2006 2006, Article ID 60291, 10 pages

Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece

Received 25 June 2006; Revised 27 August 2006; Accepted 8 September 2006

Copyright © 2006 Sotiris K. Hadjikakou and Nick Hadjiliadis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We review the results of our work on the iodine interaction withthioamides, selenoamides, and amides. Complexes with i “spoke” or “extendedspoke” structures, D⋅I2 and D⋅I2⋅I2, respectively, D is the ligand donor ii iodonium salts of{D2−I+In−} n=3, 7 and {D2−I+FeCl4−} formulae and iii disulfides of the categoriesa D-D, b {D-DH+I3−} have been isolated andcharacterized. A compound of formula {D2−I+I3−D⋅I2} containing both types of complexesi and ii was also isolated.The interaction of diiodine with selenium analogs of the antithyroid drug 6-n-propyl-2-thiouracil PTU, of formulae RSeU 6-alkyl-2-Selenouracil results in the formation of complexes with formulae RSeUI2. All these results are correlated with the mechanism ofaction of antithyroid drugs. Finally, we review here our work on the diiodine interactionwith the amides LO.

Author: Sotiris K. Hadjikakou and Nick Hadjiliadis



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