Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1Reportar como inadecuado




Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Mediators of Inflammation - Volume 2006 2006, Article ID 60285, 6 pages

Research Communication Department of Experimental Medicine, Second University of Naples, Naples 80138, Italy

Received 23 February 2006; Revised 7 April 2006; Accepted 10 April 2006

Copyright © 2006 Settimio Rossi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study investigated the heme oxygenase-1 HO-1 and theendotoxin-induced uveitis EIU in diabetic streptozotocinSTZ-hyperglycemic rats. STZ-hyperglycemic rats had impairedlevels of the enzyme HO-1 within the ciliary bodies ifcompared with the nondiabetic rats. STZ-hyperglycemic rats alsopredisposed the eye to produce high levels of both the cytokinesIL-1β and CXCL8. Subsequent EIU further and significantlyP<.01 increased the cytokines production, an effect partlyprevented by hemin treatment. Most importantly, hemin, an inducerof heme oxygenase expression and activity, recovered the hugenumber of infiltrated polymorphonuclear leukocytes PMN within theciliary bodies associated with STZ-hyperglycemic state and EIUdamage. Impairment of the stress-sensitive enzyme HO-1 inSTZ-hyperglycemic rats increases and prolongs the inflammatoryresponse to EIU.





Autor: Settimio Rossi, Michele D-Amico, Annalisa Capuano, Mary Romano, Pasquale Petronella, and Clara Di Filippo

Fuente: https://www.hindawi.com/



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