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Journal of Neural Transplantation - Volume 1 1989, Issue 1, Pages 23-31



Division of Neuroscience, Departments of Psychiatry, Neurosurgery, Psychology, and Physiology, University of Cincinnati College of Medicine, 231 Bethesda. Avenue, Cincinnati, Ohio 45267-0559, USA

Department of Neurobiology and Anatomy, University of Rochester Medical School, Rochester, New York 14642, USA



Copyright © 1989 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rats which receive injections of kainic acid KA into the striatum show many of the anatomical, biochemicaland behavioral abnormalities seen in patients with Huntington-s disease. Recently, it has been reported thatfetal striatal transplants into the lesioned striatum could normalize the neurological and behavioral abnormalitiesproduced by the KA lesion. The present study examined the issue of transplant integration in producing behavioralrecovery. In one experiment, lesioned animals with transplants located within the lateral ventricle werecompared against parenchymally transplanted rats. It was found that unless the ventricular transplant grewinto the lesioned striatum there was no recovery. The second experiment demonstrated that electrolytic destructionof a successful fetal striatal transplant could reverse the transplant-induced behavioral recovery. Theseresults suggest that the integrity of the transplant is important in maintaining behavioral recovery. A continuingfunctional interaction between the host brain and transplanted tissue may be a vital element in thesuccess of the fetal striatal transplant.





Autor: Paul R. Sanberg, Magda Giòrdano, Mark A. Henault, David R. Nash, Michael E. Ragozzino, and Starr H. Hagenmeyer-Houser

Fuente: https://www.hindawi.com/



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