Prevalence of HIV Antiretroviral Drug Resistance and Its Impacts on HIV-1 Virological Failures in Jiangsu, China: A Cross-Sectional StudyReportar como inadecuado




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BioMed Research International - Volume 2016 2016, Article ID 1752437, 7 pages -

Research Article

Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, China

College of Agriculture, Nanjing Agriculture University, Nanjing, China

Received 13 July 2016; Accepted 18 September 2016

Academic Editor: Lei Zhang

Copyright © 2016 Ying Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antiretroviral therapy ART has been shown to improve survival of patients with Human Immunodeficiency Virus HIV infection and to reduce HIV-1 transmission. Therefore, the Chinese central government initiated a national program to provide ART free of charge to HIV-1 patients. We conducted a cross-sectional survey in Jiangsu province to determine the level of drug resistance DR in HIV-1 infected patients and the correlates of DR in virological failures in 2012. Approximately 10.4% of the HIV-1 patients in the study experienced virological failure after one year of ART and were divided into drug sensitive and drug resistant groups based on genotype determination. The viral loads VLs in the drug resistant group were significantly lower than the drug sensitive group. There were two independent predictors of virological failure: male gender and increasing duration of treatment. The primary mutations observed in the study were against nucleoside reverse transcriptase inhibitors NRTIs which were M184V 79.45% and K103N 33.70% in nonnucleoside reverse transcriptase inhibitors NNRTIs. The overall rate of DR in Jiangsu province is still relatively low among treated patients. However, close monitoring of drug resistance in male patients in the early stages of treatment is vital to maintaining and increasing the benefits of HIV ART achieved to date.





Autor: Ying Zhou, Jing Lu, Jinge Wang, Hongjing Yan, Jianjun Li, Xiaoqin Xu, Zhi Zhang, Tao Qiu, Ping Ding, Gengfeng Fu, Xiping

Fuente: https://www.hindawi.com/



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