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* Corresponding author 1 LDPM - Laboratoire Dynamique des Protéines et Modélisation 2 Hemostase, Endothelium, Angiogenese 3 MAPMO - Mathématiques - Analyse, Probabilités, Modélisation - Orléans

Abstract : Red blood cell hemodynamics influence blood rheology and thus circulatory function. Different authors showed that red blood cells are heterogeneous in blood flow. This heterogeneity could be explained by physical characteristics such as morphology, aggregability and deformability, but also by cellular and molecular environment. All these notions are found in sickle cell disease where sickle red blood cells become more rigid, leading to vascular occlusions, increased with an inflammatory context. In a preceding study, our results showed that velocity heterogeneity allow RBC classification, leading to different RBC sub-groups, using a dynamical approach and flow studies. In order to have a better understanding of the physiological meaning of such an heterogeneity, dynamical velocity experiences have been conducted in the case of normal and sickle red blood cells with different endothelial activations by proinflammatory cytokines, under a constant venular flow. Thus, normal and sickle red blood cells are classified into different sub-groups, showing their heterogeneity. Moreover, sub-population velocities and distribution evolve differently according to vascular state or treatment. These results show that red blood cell velocities and rheology depend on vascular environment and red blood cell morphology. However, the physiological meaning of this behavior should be explained by cellular and molecular effects of such activation.

Keywords : Velocity. Adhesion Blood flow Hemodynamics Sickle red blood cell Velocity

Autor: Clara Allayous - Arlette Bruel - Damien Schoëvaërt - Richard Emilion - Therese Marianne-Pepin -



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