Current Immunotherapies for Sarcoma: Clinical Trials and RationaleReportar como inadecuado




Current Immunotherapies for Sarcoma: Clinical Trials and Rationale - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Sarcoma - Volume 2016 2016, Article ID 9757219, 6 pages -

Review Article

Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received 27 June 2016; Accepted 24 August 2016

Academic Editor: Mustafa Benekli

Copyright © 2016 Demytra Mitsis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sarcoma tumors are rare and heterogeneous, yet they possess many characteristics that may facilitate immunotherapeutic responses. Both active strategies including vaccines and passive strategies involving cellular adoptive immunotherapy have been applied clinically. Results of these clinical trials indicate a distinct benefit for select patients. The recent breakthrough of immunologic checkpoint inhibition is being rapidly introduced to a variety of tumor types including sarcoma. It is anticipated that these emerging immunotherapies will exhibit clinical efficacy for a variety of sarcomas. The increasing ability to tailor immunologic therapies to sarcoma patients will undoubtedly generate further enthusiasm and clinical research for this treatment modality.





Autor: Demytra Mitsis, Valerie Francescutti, and Joseph Skitzki

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados