Anti-Phosphatidylserine-Prothrombin Antibodies Are Associated with Adverse Pregnancy OutcomesReportar como inadecuado




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Journal of Immunology Research - Volume 2015 2015, Article ID 975704, 8 pages -

Research Article

Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia

Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, SI-1000 Ljubljana, Slovenia

Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, SI-6000 Koper, Slovenia

Received 18 September 2014; Accepted 15 January 2015

Academic Editor: Nejat K. Egilmez

Copyright © 2015 Polona Žigon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To determine the prevalence and clinical association of anti-phosphatidylserine-prothrombin antibodies aPS-PT in patients with a history of pregnancy complications relevant to antiphospholipid syndrome APS. Materials and Methods. Two hundred and eleven patients with a history of a three or more consecutive miscarriages before 10th week of gestation WG , b death of a morphologically normal fetus beyond 10th WG , c premature birth of a morphologically normal neonate before 34th WG due to eclampsia, preeclamsia and placental insufficiency , and d less than three unexplained consecutive miscarriages before 10th WG . Subjects sera were analyzed for lupus anticoagulant LA, anti-cardiolipin aCL, anti-glycoprotein I anti-GPI, and aPS-PT antibodies. Results. 41-169 24.3% of patients were positive for at least one measured aPL. The highest prevalence was found for aPS-PT and aCL 13.0% and 12.4%, resp. followed by LA 7.7% and anti-GPI 7.1%. 11-169 with APS-related obstetric manifestations had only aPS-PT. 17.8% of patients were positive for LA or aCL and-or anti-GPI; however when adding the aPS-PT results, an additional 7% of patients could be evaluated for APS. Conclusion. aPS-PT are associated with recurrent early or late abortions and with premature delivery irrespective of other aPL.





Autor: Polona Žigon, Katja Perdan Pirkmajer, Matija Tomšič, Tanja Kveder, Borut Božič, Snežna Sodin Šemrl, Saša Čučnik, 

Fuente: https://www.hindawi.com/



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