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Stem Cells International - Volume 2016 2016, Article ID 9756973, 16 pages -

Review Article

Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar ICBAS, Universidade do Porto UP, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal

Centro de Estudos de Ciência Animal CECA, Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto ICETA-UP, Praça Gomes Teixeira, Apartado 55142, 4051-401 Porto, Portugal

REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal

Received 28 July 2015; Revised 12 October 2015; Accepted 16 November 2015

Academic Editor: James Adjaye

Copyright © 2016 Ana Rita Caseiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mesenchymal stem cells are posing as a promising character in the most recent therapeutic strategies and, since their discovery, extensive knowledge on their features and functions has been gained. In recent years, innovative sources have been disclosed in alternative to the bone marrow, conveying their associated ethical concerns and ease of harvest, such as the umbilical cord tissue and the dental pulp. These are also amenable of cryopreservation and thawing for desired purposes, in benefit of the donor itself or other patients in pressing need. These sources present promising possibilities in becoming useful cell sources for therapeutic applications in the forthcoming years. Effective and potential applications of these cellular-based strategies for the regeneration of peripheral nerve are overviewed, documenting recent advances and identified issues for this research area in the near future. Finally, besides the differentiation capacities attributed to mesenchymal stem cells, advances in the recognition of their effective mode of action in the regenerative theatre have led to a new area of interest: the mesenchymal stem cells’ secretome. The paracrine modulatory pathway appears to be a major mechanism by which these are beneficial to nerve regeneration and comprehension on the specific growth factors, cytokine, and extracellular molecules secretion profiles is therefore of great interest.





Autor: Ana Rita Caseiro, Tiago Pereira, Galya Ivanova, Ana Lúcia Luís, and Ana Colette Maurício

Fuente: https://www.hindawi.com/



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