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Comparative and Functional Genomics - Volume 2 2001, Issue 4, Pages 236-242

Review Institute of Biological Sciences, University of Wales Aberystwyth, Aberystwyth, Wales SY23 3DA, UK

Received 26 June 2001; Accepted 27 June 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the year 2001 a collection of yeast strains will be completed that are deleted in the 6000open reading frames selected as putative genes by the initial bioinformatic analysis of theSaccharomyces cerevisiae genome. The collection was produced by the transatlantic yeastgene deletion project, a collaboration involving researchers in the USA, Canada andEurope. The European effort was part of EUROFAN European Functional AnalysisNetwork where some of the strains could feed into various functional analysis nodesdealing with specific areas of cell biology. With approximately 40% of human genesinvolved in heritable disease having a homologue in yeast and with the use of yeast invarious drug discovery strategies, not least due to the dramatic increase in fungalinfections, these strains will be valuable in trans-genomic studies and in specialised intereststudies in individual laboratories. A detailed analysis of the project by the consortium is inpreparation, here we discuss the yeast strains, reported findings and approaches to usingthis resource.

Autor: Diane E. Kelly, David C. Lamb, and Steven L. Kelly



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