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Biology Direct

, 3:3

First Online: 28 January 2008Received: 13 November 2007Accepted: 28 January 2008


Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about polypeptide three-dimensional structure to predict the types of conformations they would have adopted. The possible existence of such structures at this time leads to a consideration of their functional significance, and the consequences for the course of evolution.

This article was reviewed by Bill Martin, Eugene Koonin and Nick Grishin.

Electronic supplementary materialThe online version of this article doi:10.1186-1745-6150-3-3 contains supplementary material, which is available to authorized users.

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Autor: E James Milner-White - Michael J Russell


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