TrED: the Trichophyton rubrum Expression DatabaseReportar como inadecuado




TrED: the Trichophyton rubrum Expression Database - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Genomics

, 8:250

First Online: 25 July 2007Received: 27 April 2007Accepted: 25 July 2007

Abstract

BackgroundTrichophyton rubrum is the most common dermatophyte species and the most frequent cause of fungal skin infections in humans worldwide. It-s a major concern because feet and nail infections caused by this organism is extremely difficult to cure. A large set of expression data including expressed sequence tags ESTs and transcriptional profiles of this important fungal pathogen are now available. Careful analysis of these data can give valuable information about potential virulence factors, antigens and novel metabolic pathways. We intend to create an integrated database TrED to facilitate the study of dermatophytes, and enhance the development of effective diagnostic and treatment strategies.

DescriptionAll publicly available ESTs and expression profiles of T. rubrum during conidial germination in time-course experiments and challenged with antifungal agents are deposited in the database. In addition, comparative genomics hybridization results of 22 dermatophytic fungi strains from three genera, Trichophyton, Microsporum and Epidermophyton, are also included. ESTs are clustered and assembled to elongate the sequence length and abate redundancy. TrED provides functional analysis based on GenBank, Pfam, and KOG databases, along with KEGG pathway and GO vocabulary. It is integrated with a suite of custom web-based tools that facilitate querying and retrieving various EST properties, visualization and comparison of transcriptional profiles, and sequence-similarity searching by BLAST.

ConclusionTrED is built upon a relational database, with a web interface offering analytic functions, to provide integrated access to various expression data of T. rubrum and comparative results of dermatophytes. It is devoted to be a comprehensive resource and platform to assist functional genomic studies in dermatophytes. TrED is available from URL: http:-www.mgc.ac.cn-TrED-.

Jian Yang, Lihong Chen contributed equally to this work.

Download fulltext PDF



Autor: Jian Yang - Lihong Chen - Lingling Wang - Wenliang Zhang - Tao Liu - Qi Jin

Fuente: https://link.springer.com/article/10.1186/1471-2164-8-250







Documentos relacionados