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BMC Evolutionary Biology

, 7:120

First Online: 18 July 2007Received: 19 January 2007Accepted: 18 July 2007

Abstract

BackgroundThe Class I cytokine receptors have a wide range of actions, including a major role in the development and function of immune and blood cells. However, the evolution of the genes encoding them remains poorly understood. To address this we have used bioinformatics to analyze the Class I receptor repertoire in sea squirt Ciona intestinalis and zebrafish Danio rerio.

ResultsOnly two Class I receptors were identified in sea squirt, one with homology to the archetypal GP130 receptor, and the other with high conservation with the divergent orphan receptor CLF-3. In contrast, 36 Class I cytokine receptors were present in zebrafish, including representative members for each of the five structural groups found in mammals. This allowed the identification of 27 core receptors belonging to the last common ancestor of teleosts and mammals.

ConclusionThis study suggests that the majority of diversification of this receptor family occurred after the divergence of urochordates and vertebrates approximately 794 million years ago MYA, but before the divergence of ray-finned from lobe-finned fishes around 476 MYA. Since then, only relatively limited lineage-specific diversification within the different Class I receptor structural groups has occurred.

AbbreviationsBLASTBasic local alignment search tool

CHDCytokine receptor homology domain

CLFCytokine receptor like factor

CNTFCiliary neurotrophic factor

CSFColony-stimulating factor

CRFACytokine receptor family Class I

EPORErythropoietin receptor

ESTExpressed sequence tag

FBNFibronectin

GCSFGranulocyte-CSF

GHGrowth hormone

GLMRGP130-like monocyte receptor

GP130Glycoprotein 130

HPFHours post fertilization

IFNInterferon

ILInterleukin

JAKJanus Kinase

LIFLeukemia inhibitory factor

MYAMillion years ago

OBobesity leptin

OSMOncostatin M

PRLProlactin

RReceptor

SLSomatolactin

STATSignal transducers and activators of transcription

TMTransmembrane

TNFTumor necrosis factor

TPOThrombopoietin

TSLPThymic stromal lymphopoietin

WGSWhole genome shotgun

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2148-7-120 contains supplementary material, which is available to authorized users.

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Autor: Clifford Liongue - Alister C Ward

Fuente: https://link.springer.com/article/10.1186/1471-2148-7-120



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