Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical TrialReportar como inadecuado




Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Evidence-Based Complementary and Alternative Medicine - Volume 2016 2016, Article ID 8983232, 10 pages -

Research Article

Department of Food Science and Nutrition, Hallym University, 1 Hallymdeahak-gil, Chuncheon 24252, Republic of Korea

Department of Pharmacology, College of Medicine, Hallym University, 1 Hallymdeahak-gil, Chuncheon 24252, Republic of Korea

Department of Physical Education, Hallym University, 1 Hallymdeahak-gil, Chuncheon 24252, Republic of Korea

College of Food Science and Engineering, Jinzhou Medical University, Jinzhou 121001, China

Received 16 August 2016; Revised 22 October 2016; Accepted 24 October 2016

Academic Editor: Roja Rahimi

Copyright © 2016 Seung Hwan Hwang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To evaluate the antihyperglycemic effect of a standardized extract of the leaves of Morus alba SEMA, the present study was designed to investigate the α-glucosidase inhibitory effect and acute single oral toxicity as well as evaluate blood glucose reduction in animals and in patients with impaired glucose tolerance in a randomized double-blind clinical trial. SEMA was found to inhibit α-glucosidase at a fourfold higher level than the positive control acarbose, in a concentration-dependent manner. Moreover, blood glucose concentration was suppressed by SEMA in vivo. Clinical signs and weight changes were observed when conducting an evaluation of the acute toxicity of SEMA through a single-time administration, with clinical observation conducted more than once each day. After administration of the SEMA, observation was for 14 days; all of the animals did not die and did not show any abnormal symptoms. In addition, the inhibitory effects of rice coated with SEMA were evaluated in a group of impaired glucose tolerance patients on postprandial glucose and a group of normal persons, and results showed that SEMA had a clear inhibitory effect on postprandial hyperglycemia in both groups. Overall, SEMA showed excellent potential in the present study as a material for improving postprandial hyperglycemia.





Autor: Seung Hwan Hwang, Hong Mei Li, Soon Sung Lim, Zhiqiang Wang, Jae-Seung Hong, and Bo Huang

Fuente: https://www.hindawi.com/



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