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BMC Genomics

, 6:173

First Online: 06 December 2005Received: 30 August 2005Accepted: 06 December 2005

Abstract

BackgroundVertebrate odorant receptors comprise three types of G protein-coupled receptors: the OR, V1R and V2R receptors. The OR superfamily contains over 1,000 genes in some mammalian species, representing the largest gene superfamily in the mammalian genome.

ResultsTo facilitate an informed analysis of OR gene phylogeny, we identified the complete set of 143 OR genes in the zebrafish genome, as well as the OR repertoires in two pufferfish species, fugu 44 genes and tetraodon 42 genes. Although the genomes analyzed here contain fewer genes than in mammalian species, the teleost OR genes can be grouped into a larger number of major clades, representing greater overall OR diversity in the fish.

ConclusionBased on the phylogeny of fish and mammalian repertoires, we propose a model for OR gene evolution in which different ancestral OR genes or gene families were selectively lost or expanded in different vertebrate lineages. In addition, our calculations of the ratios of non-synonymous to synonymous codon substitutions among more recently expanding OR subgroups in zebrafish implicate residues that may be involved in odorant binding.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2164-6-173 contains supplementary material, which is available to authorized users.

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Autor: Tyler S Alioto - John Ngai

Fuente: https://link.springer.com/article/10.1186/1471-2164-6-173







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