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BioMed Research International - Volume 2014 2014, Article ID 856907, 11 pages -

Review Article

Reproductive Unit, Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Slajmerjeva 3, 1000 Ljubljana, Slovenia

European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany

Received 7 January 2014; Accepted 13 February 2014; Published 3 April 2014

Academic Editor: John Huntriss

Copyright © 2014 Irma Virant-Klun and Jeroen Krijgsveld. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oocytes are crucial cells for mammalian reproduction, yet the molecular principles underlying oocyte development are only partially understood. Therefore, contemporary proteomic approaches have been used increasingly to provide new insights into oocyte quality and maturation in various species such as mouse, pig, and cow. Especially, animal studies have helped in elucidating the molecular status of oocytes during in vitro maturation and other procedures of assisted reproduction. The aim of this review is to summarize the literature on mammalian oocyte proteome and secretome research in the light of natural and assisted reproduction and on lessons to be learned for human oocytes, which have so far remained inaccessible for proteome analysis.





Autor: Irma Virant-Klun and Jeroen Krijgsveld

Fuente: https://www.hindawi.com/



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