Discovery of a Novel Molecule that Regulates Tumor Growth and MetastasisReportar como inadecuado

Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

TheScientificWorldJOURNAL - Volume 8 2008, Pages 1250-1253

Directions in Science

Department of Medicine, Department of Pharmacology and Toxicology, and the Norris Cotton Comprehensive Cancer Center, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Hanover, NH, USA

Department of Development and Cell Biology, University of California, Irvine, USA

Received 1 August 2008; Revised 12 November 2008; Accepted 24 November 2008

Academic Editor: Peter Little

Copyright © 2008 Chery A. Whipple et al.


The heparan sulfate proteoglycan, Glypican-1 GPC1, significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

Autor: Chery A. Whipple, Arthur D. Lander, and Murray Korc



Documentos relacionados