Is Stimulated Thyroglobulin Necessary after Ablation in All Patients with Papillary Thyroid Carcinoma and Basal Thyroglobulin Detectable by a Second-Generation AssayReportar como inadecuado




Is Stimulated Thyroglobulin Necessary after Ablation in All Patients with Papillary Thyroid Carcinoma and Basal Thyroglobulin Detectable by a Second-Generation Assay - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

International Journal of Endocrinology - Volume 2015 2015, Article ID 796471, 5 pages -

Research Article

Postgraduate Program, Santa Casa de Belo Horizonte, 590 Domingos Vieira Street, 30150340 Belo Horizonte, MG, Brazil

Endocrinology Service, Santa Casa de Belo Horizonte, 1111 Francisco Sales Avenue, 30150221 Belo Horizonte, MG, Brazil

Received 26 May 2015; Accepted 3 August 2015

Academic Editor: Thomas J. Fahey

Copyright © 2015 Pedro Weslley Rosario et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the percentage of elevated stimulated thyroglobulin sTg and persistent or recurrent disease PRD in patients with detectable basal Tg < 0.3 ng-mL. Methods. The sample consisted of 130 patients with papillary thyroid carcinoma PTC who were at low risk of PRD and who had neck ultrasound US without abnormalities, negative anti-Tg antibodies TgAb, and detectable basal Tg < 0.3 ng-mL about 6 months after ablation. Results. sTg was <1 ng-mL in 88 patients 67.7%, between 1 and 2 ng-mL in 26 20%, and ≥2 ng-mL in 16 12.3%. Imaging methods revealed the absence of tumors in 16 patients with elevated sTg. During follow-up, Tg increased to 0.58 ng-mL in one patient and lymph node metastases were detected. Sixty-nine patients continued to have detectable Tg < 0.3 ng-mL and US revealed recurrence in only one patient. Sixty patients progressed to persistently undetectable Tg without apparent disease on US. Conclusions. In low-risk patients with PTC who have detectable basal Tg < 0.3 ng-mL after ablation, negative TgAb, and US, persistent disease is rare and eventual recurrences can be detected by basal Tg elevation and-or subsequent US assessments, with follow-up without sTg being an -alternative- to Tg stimulation.





Autor: Pedro Weslley Rosario, Gabriela Franco Mourão, and Maria Regina Calsolari

Fuente: https://www.hindawi.com/



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