FGF signaling inhibits the proliferation of human myeloma cells and reduces c-myc expressionReportar como inadecuado




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BMC Cell Biology

, 4:17

First Online: 04 December 2003Received: 12 May 2003Accepted: 04 December 2003

Abstract

BackgroundMultiple myeloma is a cancer of antibody producing plasma cells whose etiology is unknown. FGF signaling has been implicated in myeloma pathogenesis but its precise role remains unclear.

ResultsHere, we investigate the biochemical and phenotypic consequences of FGF stimulation in several different human myeloma cell lines. We find that FGF signaling inhibits cell cycle progression in two lines and surprisingly, reduces the expression of c-myc while turning on c-fos. In several other lines, FGF signaling does not affect proliferation rate, including cells harboring translocated FGF Receptor 3. When cells are presented with a growth arrest signal, FGF addition induces cell death.

ConclusionsBy showing that FGF signaling inhibits mitogenesis and induces apoptosis, we demonstrate novel effects of activating this ubiquitous signaling pathway in multiple myeloma.

KeywordsFGF multiple myeloma c-myc apoptosis oncogene Electronic supplementary materialThe online version of this article doi:10.1186-1471-2121-4-17 contains supplementary material, which is available to authorized users.

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Autor: Louise Firme - Andrew B Bush

Fuente: https://link.springer.com/article/10.1186/1471-2121-4-17







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