TnpPred: A Web Service for the Robust Prediction of Prokaryotic TransposasesReport as inadecuate

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Comparative and Functional GenomicsVolume 2012 2012, Article ID 678761, 5 pages

Research Article

Center for Bioinformatics and Genome Biology, Fundación Ciencia para la Vida Y Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile

Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile

Received 1 June 2012; Revised 20 August 2012; Accepted 18 September 2012

Academic Editor: G. Pesole

Copyright © 2012 Gonzalo Riadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Transposases Tnps are enzymes that participate in the movement of insertion sequences ISs within and between genomes. Genesthat encode Tnps are amongst the most abundant and widely distributed genes in nature. However, they are difficult topredict bioinformatically and given the increasing availability of prokaryotic genomes and metagenomes, it is incumbent to developrapid, high quality automatic annotation of ISs. This need prompted us to develop a web service, termed TnpPred for Tnpdiscovery. It provides better sensitivity and specificity for Tnp predictions than given by currently available programs asdetermined by ROC analysis. TnpPred should be useful for improving genome annotation. The TnpPred web service is freely available fornoncommercial use.

Author: Gonzalo Riadi, Cristobal Medina-Moenne, and David S. Holmes



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