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Journal of Diabetes Research - Volume 2015 2015, Article ID 678756, 8 pages -

Research Article

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan

Received 1 April 2015; Accepted 8 June 2015

Academic Editor: Hiroshi Okamoto

Copyright © 2015 Chin-Hsiao Tseng. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To evaluate whether insulin use was predictive for mortality from breast cancer in Taiwanese women with diabetes mellitus. Methods. A total of 48,880 diabetic women were followed up to determine the mortality from breast cancer during 1995–2006. Cox models were used, considering the following independent variables: age, sex, diabetes type, diabetes duration, body mass index, smoking, insulin use, and area of residence. Insulin use was also considered for its duration of use at cutoffs of 3 years and 5 years. Results. Age was a significant predictor in all analyses. The multivariable-adjusted hazard ratio 95% confidence interval, P value for insulin use without considering the duration of use was not statistically significant 1.339 0.782–2.293, . Compared with nonusers, insulin users showed the following adjusted hazard ratios for insulin use <3 years, 3 years, <5 years, and ≥5 years: 0.567 0.179–1.791, , 2.006 1.102–3.653, , 1.045 0.505–2.162, , and 1.899 0.934–3.860, . Conclusions. Insulin use mainly human insulin for ≥3 years may be associated with a higher risk of breast cancer mortality.

Autor: Chin-Hsiao Tseng



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