Systemic tobramycin concentrations during selective decontamination of the digestive tract in intensive care unit patients on continuous venovenous hemofiltrationReportar como inadecuado




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Intensive Care Medicine

, Volume 34, Issue 5, pp 903–906

First Online: 19 February 2008Received: 21 December 2007Accepted: 15 January 2008

Abstract

ObjectiveTo study whether selective decontamination of the digestive tract SDD results in detectable serum tobramycin concentrations in intensive care unit ICU patients with acute renal failure treated with continuous venovenous hemofiltration CVVH.

Design and settingProspective, observational, single-center study in a mixed medical–surgical ICU.

PatientsAdult ICU patients receiving SDD for at least 3 days and being treated with CVVH because of acute renal failure.

Measurements and resultsTobramycin serum concentrations were measured at the 3rd day after start of CVVH and every 3 days thereafter. Detectable serum concentrations of tobramycin were found in 12 63% of 19 patients and in 15 58% of the 26 samples. With a toxic tobramycin concentration defined as more than 2.0 mg-l, we found one patient with a toxic concentration of 3.0 mg-l. In three other patients tobramycin concentrations of ≥ 1.0 mg-l were found.

ConclusionsIn patients with acute renal failure treated with CVVH, administration of SDD with tobramycin can lead to detectable and potentially toxic serum tobramycin concentrations.

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Autor: Meriel Mol - Hendrikus J. M. van Kan - Marcus J. Schultz - Evert de Jonge

Fuente: https://link.springer.com/







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