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Comparative and Functional Genomics - Volume 3 2002, Issue 6, Pages 494-498

Conference review Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16-10 Miklukho-Maklaya, Moscow 117997, Russia

Received 4 September 2002; Accepted 9 October 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Humans share about 99% of their genomic DNA with chimpanzees and bonobos; thus, the differences between these species are unlikely to be in gene content but could becaused by inherited changes in regulatory systems. Endogenous retroviruses ERVscomprise ∼ 5% of the human genome. The LTRs of ERVs contain many regulatorysequences, such as promoters, enhancers, polyadenylation signals and factor-bindingsites. Thus, they can influence the expression of nearby human genes. All knownhuman-specific LTRs belong to the HERV-K human ERV family, the most activefamily in the human genome. It is likely that some of these ERVs could have integratedinto regulatory regions of the human genome, and therefore could have had an impacton the expression of adjacent genes, which have consequently contributed to humanevolution. This review discusses possible functional consequences of ERV integrationin active coding regions.





Autor: Konstantin Khodosevich, Yuri Lebedev, and Eugene Sverdlov

Fuente: https://www.hindawi.com/



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