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Evidence-Based Complementary and Alternative Medicine - Volume 2015 2015, Article ID 265303, 9 pages -

Research Article

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China

Pharmacy School, Zunyi Medical College, Zunyi, Guizhou 563000, China

Received 21 December 2014; Accepted 23 February 2015

Academic Editor: Swee Ngin Tan

Copyright © 2015 Xiangjun Kong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A comprehensive understanding of the integrative nature of the molecular network in thrombosis would be very helpful to develop multicomponent and multitarget antithrombosis drugs for use in traditional Chinese medicine TCM. This paper attempts to comprehensively map the molecular network in thrombosis by combining platelet signaling, the coagulation cascade, and natural clot dissolution systems and to analyze the topological characteristics of the network, including the centralities of nodes, network modules, and network robustness. The results in this research advance understanding of functions of proteins in the thrombosis network and provide a reference for predicting potential therapeutic antithrombotic targets and evaluating their influence on the network.





Autor: Xiangjun Kong, Wenxia Zhou, Jian-Bo Wan, Qianru Zhang, Jingyun Ni, and Yuanjia Hu

Fuente: https://www.hindawi.com/



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