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International Journal of HepatologyVolume 2012 2012, Article ID 231210, 10 pages

Research Article

In Vitro Drug Safety and Biotechnology, MaRS Discovery Centre, 101 College Street, South Tower, Toronto, ON, Canada M5G 1L7

Department of Pharmacology and Toxicology and Institute of Drug Research, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

Gastroenterology Unit, Gastroenterology Division, Rabin Medical Center, Hasharon-Golda Campus, 7 Keren Kayemet St., Petach-Tiqwa 49372, Israel

Division of Gastroenterology, Department of Medicine, Hepatitis SMBD—Jewish General Hospital Montreal, McGill University School of Medicine, 3755 Chemin de la Cote-St-Catherine, Montreal, QC, Canada H3T 1E2

Department of Hepato-Gastroenterology, Saint-Joseph Hospital, Marseille, France

Service Hepato-Gastroenterology, Hopital Beaujon, Clichy, France

Hopital de la Croix Rousse, 103, Grande Rue de la Croix-Rousse, 69317, Lyon Cedex 04, France

Department of Microbiology, Mount Sinai Hospital and Department of Laboratory Medicine, University of Toronto, 550 University Av., Toronto, ON, Canada M5G 1L7

Division of Gastroenterology, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5

Received 31 July 2011; Revised 31 October 2011; Accepted 23 November 2011

Academic Editor: Kusum Kharbanda

Copyright © 2012 Manuela G. Neuman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High levels of profibrinogenic cytokine transforming factor beta TGF-β, metalloprotease MMP2, and tissue inhibitor of matrix metalloprotease 1 TIMP1 contribute to fibrogenesis in hepatitis C virus HCV infection and in alcohol-induced liver disease ALD. The aim of our study was to correlate noninvasive serum markers in ALD and HCV patients with various degrees of inflammation and fibrosis in their biopsies. Methods. Serum cytokines levels in HCV-infected individuals in the presence or absence of ALD were measured. Student-s-t-test with Bonferroni correction determined the significance between the groups. Results. Both tumor-necrosis-factor- TNF-α and TGF-β levels increased significantly with the severity of inflammation and fibrosis. TGF-β levels increased significantly in ALD patients versus the HCV patients. Proinflammatory cytokines’ responses to viral and-or toxic injury differed with the severity of liver inflammation. A combination of these markers was useful in predicting and diagnosing the stages of inflammation and fibrosis in HCV and ALD. Conclusion. Therapeutic monitoring of TGF-β and metalloproteases provides important insights into fibrosis.

Autor: Manuela G. Neuman, Hemda Schmilovitz-Weiss, Nir Hilzenrat, Marc Bourliere, Patrick Marcellin, Cristhian Trepo, Tony Mazulli,



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