MRC chronic Dyspnea Scale: Relationships with cardiopulmonary exercise testing and 6-minute walk test in idiopathic pulmonary fibrosis patients: a prospective studyReportar como inadecuado




MRC chronic Dyspnea Scale: Relationships with cardiopulmonary exercise testing and 6-minute walk test in idiopathic pulmonary fibrosis patients: a prospective study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Pulmonary Medicine

, 10:32

First Online: 28 May 2010Received: 10 January 2010Accepted: 28 May 2010

Abstract

BackgroundExertional dyspnea is the most prominent and disabling feature in idiopathic pulmonary fibrosis IPF. The Medical Research Chronic MRC chronic dyspnea score as well as physiological measurements obtained during cardiopulmonary exercise testing CPET and the 6-minute walk test 6MWT are shown to provide information on the severity and survival of disease.

MethodsWe prospectively recruited IPF patients and examined the relationship between the MRC score and either CPET or 6MWT parameters known to reflect physiologic derangements limiting exercise capacity in IPF patients

ResultsTwenty-five patients with IPF were included in the study. Significant correlations were found between the MRC score and the distance r = -.781, p < 0.001, the SPO2 at the initiation and the end r = -.542, p = 0.005 and r = -.713, p < 0.001 respectively and the desaturation index r = .634, p = 0.001 for the 6MWT; the MRC score and VO2 peak-kg r = -.731, p < 0.001, SPO2 at peak exercise r = -. 682, p < 0.001, VE-VCO2 slope r = .731, p < 0.001, VE-VCO2 at AT r = .630, p = 0.002 and the Borg scale at peak exercise r = .50, p = 0.01 for the CPET. In multiple logistic regression analysis, the only variable independently related to the MRC is the distance walked at the 6MWT.

ConclusionIn this population of IPF patients a good correlation was found between the MRC chronic dyspnoea score and physiological parameters obtained during maximal and submaximal exercise testing known to reflect ventilatory impairment and exercise limitation as well as disease severity and survival. This finding is described for the first time in the literature in this group of patients as far as we know and could explain why a simple chronic dyspnea score provides reliable prognostic information on IPF.

AbbreviationsATanaerobic threshold

BRbreathing reserve

CPETcardiopulmonary exercise testing

HRHeart rate

HRRHeart rate recovery

HRResHeart rate reserve

IPFIdiopathic pulmonary fibrosis

MRCMedical Research Chronic

VEminute ventilation

6MWT6-minute walk test

O2Poxygen pulse

SPO2oxygen saturation

PFTsPulmonary Functional Tests

VO2 peakpeak oxygen consumption

VO2 peak-Kgpeak oxygen consumption-Kg

RRrespiratory rate

VTtidal volume

VT-ICtidal volume-inspiratory capacity

VEtotal ventilation.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-10-32 contains supplementary material, which is available to authorized users.

Effrosyni D Manali, Panagiotis Lyberopoulos contributed equally to this work.

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Autor: Effrosyni D Manali - Panagiotis Lyberopoulos - Christina Triantafillidou - Likourgos F Kolilekas - Christina Sotiropoulou -

Fuente: https://link.springer.com/







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