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Disease Markers - Volume 2015 2015, Article ID 231063, 8 pages -

Research Article

Danone Research, 91767 Palaiseau, France

Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, CT 06269, USA

Service des Explorations Fonctionnelles Physiologiques et INSERM 1048, Equipe 12, CHU de Rangueil, 31432 Toulouse, France

Received 15 January 2015; Accepted 6 March 2015

Academic Editor: Gad Rennert

Copyright © 2015 Erica T. Perrier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


While associations exist between water, hydration, and disease risk, research quantifying the dose-response effect of water on health is limited. Thus, the water intake necessary to maintain optimal hydration from a physiological and health standpoint remains unclear. The aim of this analysis was to derive a 24 h urine osmolality UOsm threshold that would provide an index of “optimal hydration,” sufficient to compensate water losses and also be biologically significant relative to the risk of disease. Ninety-five adults 31.5 ± 4.3 years, 23.2 ± 2.7 kg·m

collected 24 h urine, provided morning blood samples, and completed food and fluid intake diaries over 3 consecutive weekdays. A UOsm threshold was derived using 3 approaches, taking into account European dietary reference values for water; total fluid intake, and urine volumes associated with reduced risk for lithiasis and chronic kidney disease and plasma vasopressin concentration. The aggregate of these approaches suggest that a 24 h urine osmolality ≤500 mOsm·kg

may be a simple indicator of optimal hydration, representing a total daily fluid intake adequate to compensate for daily losses, ensure urinary output sufficient to reduce the risk of urolithiasis and renal function decline, and avoid elevated plasma vasopressin concentrations mediating the increased antidiuretic effort.

Autor: Erica T. Perrier, Inmaculada Buendia-Jimenez, Mariacristina Vecchio, Lawrence E. Armstrong, Ivan Tack, and Alexis Klein



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