Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive RatsReportar como inadecuado




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Evidence-Based Complementary and Alternative Medicine - Volume 2014 2014, Article ID 565784, 9 pages -

Research Article

Guangxi University of Chinese Medicine, Nanning 530001, China

Affiliated Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530001, China

Received 10 October 2013; Revised 13 January 2014; Accepted 9 February 2014; Published 12 March 2014

Academic Editor: Samra Bashir

Copyright © 2014 Gui-Hua Yue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension effects of Huanglian Jiedu Decoction HJD on thoracic aorta gene expression in spontaneous hypertensive rats. Methods. A rat model of spontaneous hypertension was used. The gene change profile of thoracic aorta after JHD treatment was assessed by GeneChipGC analysis using the Agilent Whole Rat Genome Oligo Microarray. Results. Hypertension induced 441 genes upregulated and 417 genes downregulated compared with the normal control group. Treatment of HJD resulted in 76 genes downregulated and 20 genes upregulated. GC data analysis showed that the majority of change genes were involved in immune system process, developmental process, and cell death. Conclusion. Hypertension altered expression of many genes that regulate various biological functions. HJD significantly reduced hypertension and altered the gene expression profiles of SHR rats. These changing genes were involved in many cellular functions such as regulating smooth muscle contraction, Ca2+ homeostasis, and NO pathway. This study provides the potential novel insights into hypertension and antihypertension effects of HJD.





Autor: Gui-Hua Yue, Shao-Yuan Zhuo, Meng Xia, Zhuo Zhang, Yi-Wen Gao, and Yuan Luo

Fuente: https://www.hindawi.com/



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