BMI can influence adult males’ and females’ airway hyperresponsiveness differentlyReportar como inadecuado

BMI can influence adult males’ and females’ airway hyperresponsiveness differently - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Multidisciplinary Respiratory Medicine

, 7:45

First Online: 17 November 2012Received: 02 October 2012Accepted: 30 October 2012


BackgroundEpidemiological data indicate that obesity is a risk factor for asthma, but scientific literature is still debating the association between changes in body mass index BMI and airway hyperresponsiveness AHR.

MethodsThis study aimed at evaluating the influence of BMI on AHR, in outpatients with symptoms suggestive of asthma.

4,217 consecutive adult subjects 2,439 M; mean age: 38.2±14.9 yrs; median FEV1 % predicted: 100 IQR:91.88-107.97 and FEV1-FVC % predicted: 85.77% IQR:81.1-90.05, performed a methacholine challenge test for suspected asthma. Subjects with PD20 < 200 or 200 < PD20 < 800 or PD20 > 800 were considered affected by severe, moderate or mild AHR, respectively.

ResultsA total of 2,520 subjects 60% of all cases had a PD20 < 3,200 μg, with a median PD20 of 366 μg IQR:168–1010.5; 759, 997 and 764 patients were affected by mild, moderate and severe AHR, respectively. BMI was not associated with increasing AHR in males. On the contrary, obese females were at risk for AHR only when those with moderate AHR were considered OR: 1.772 1.250-2.512, p = 0.001. A significant reduction of FEV1-FVC for unit of BMI increase was found in moderate AHR, both in males β = −0.255; p =0.023 and in females β = −0.451; p =0.017.

ConclusionsOur findings indicate that obesity influences AHR only in females with a moderate AHR level. This influence may be mediated by obesity-associated changes in baseline lung function.

KeywordsAirway hyperresponsiveness asthma body mass index males and females methacholine test obesity Electronic supplementary materialThe online version of this article doi:10.1186-2049-6958-7-45 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Autor: Bruno Sposato - Marco Scalese - Nicola Scichilone - Andrea Pammolli - Massimo Tosti Balducci - Maria Giovanna Migliorini -


Documentos relacionados