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BMC Pulmonary Medicine

, 13:32

First Online: 31 May 2013Received: 03 August 2012Accepted: 29 May 2013


BackgroundThe role of antibiotics in treating mild or moderate exacerbations in patients with acute chronic obstructive pulmonary disease COPD is unclear. The aims were to: i describe patient characteristics associated with acute exacerbations amongst a representative COPD population, ii explore the relationship between COPD severity and outcomes amongst patients with exacerbations, and iii quantify variability by general practice in prescribing of antibiotics for COPD exacerbations.

MethodA cohort of 62,747 patients with COPD was identified from primary care general practices GP in England, and linked to hospital admission and death certificate data. Exacerbation cases were matched to three controls and characteristics compared using conditional logistic regression. Outcomes were compared using incidence rates and Cox regression, stratified by disease severity. Variability of prescribing at the GP level was evaluated graphically and by using multilevel models.

ResultsCOPD severity was found to be associated with exacerbation and subsequent mortality very severe vs. mild, odds ratio for exacerbation 2.12 95%CI 19.5–2.32, hazard ratio for mortality 2.14 95%CI 1.59–2.88. Whilst 61% of exacerbation cases were prescribed antibiotics, this proportion varied considerably between GP practices interquartile range, 48–73%. This variation is greater than can be explained by patient characteristics alone.

ConclusionsThere is significant variability between GP practices in the prescribing of antibiotics to COPD patients experiencing exacerbations. Combined with a lack of evidence on the effects of treatment, this supports the need and opportunity for a large scale pragmatic randomised trial of the prescribing of antibiotics for COPD patients with exacerbations, in order to clarify their effectiveness and long term outcomes whilst ensuring the representativeness of subjects.

KeywordsChronic obstructive pulmonary disease Disease exacerbation Clinical practice variation Anti-bacterial agents Primary health care General practice Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-13-32 contains supplementary material, which is available to authorized users.

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Autor: Rachael Boggon - Richard Hubbard - Liam Smeeth - Martin Gulliford - Jackie Cassell - Susan Eaton - Munir Pirmohamed - Tjeer


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