Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsisReportar como inadecuado




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Critical Care

, 18:R1

First Online: 02 January 2014Received: 08 July 2013Accepted: 31 October 2013

Abstract

IntroductionThe aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis.

MethodsWe evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein BPI; rs5743507, lipopolysaccharide-binding protein LBP; rs2232618, toll-like receptor 4 TLR4; rs4986790, heat shock protein 70 HSP 70; rs2227956, and interleukin 6 IL-6; rs1800795 in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables were constructed and statistically evaluated using log-linear models. Typical gene combinations were found for both study groups.

ResultsDetailed analyses of the five studied gene profiles revealed significant differences in sepsis survival. Stratification into high-risk, intermediate-risk, and low-risk groups of paediatric patients can predict the severity of sepsis.

ConclusionsAnalysis of single nucleotide polymorphisms for five genes can be used as a predictor of sepsis outcome in children.

AbbreviationsBPIBactericidal permeability increasing protein

CGControl group

HSP 70Heat shock protein A1L

IL-6Interleukin 6

LBPLipopolysaccharide-binding protein

LPSLipopolysaccharide

MODSMultiple organ dysfunction syndrome

PGPatient group

PGSPatient group with severe condition - severe sepsis septic shock or multiple organ dysfunction syndrome

PICUPaediatric intensive care unit

SNPSingle nucleotide polymorphisms

TLRToll-like receptor 4.

Electronic supplementary materialThe online version of this article doi:10.1186-cc13174 contains supplementary material, which is available to authorized users.

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Autor: Petr Jabandziev - Michal Smerek - Jaroslav MichalekSr - Michal Fedora - Lucie Kosinova - Jaroslav A Hubacek - Jaroslav Mic

Fuente: https://link.springer.com/



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