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Critical Care

, 18:136

First Online: 29 April 2014

Abstract

In view of the mortality associated with Pseudomonas aeruginosa PSA ventilator-associated pneumonia VAP and the frequency of inadequate initial empiric therapy, recent findings underscore the need for a different management paradigm with effective anti-pseudomonal vaccines for prophylaxis of patients at risk. The association of virulence factors is a variable that splits PSA in two phenotypes, with the possibility of adjunctive immunomodulatory therapy for management of virulent strains. We comment on recent advances in and the state of the art of PSA-VAP management and discuss a new paradigm for tailored and optimal management.

AbbreviationsPSAPseudomonas aeruginosa

TTSSType III secretion system

VAPVentilator-associated pneumonia.

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Autor: Jordi Rello - Bárbara Borgatta - Leonel Lagunes

Fuente: https://link.springer.com/







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