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Advances in VirologyVolume 2012 2012, Article ID 508967, 16 pages

Review Article

Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada R3E 0J9

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada R3E 3R2

Received 9 December 2011; Revised 26 February 2012; Accepted 11 March 2012

Academic Editor: Nicola Coppola

Copyright © 2012 Raghavan Sampathkumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

As of February 2012, 50 circulating recombinant forms CRFs have been reported for HIV-1 while one CRF for HIV-2. Also according to HIV sequence compendium 2011, the HIV sequence database is replete with 414,398 sequences. The fact that there are CRFs, which are an amalgamation of sequences derived from six or more subtypes CRF27_cpx cpx refers to complex is a mosaic with sequences from 6 different subtypes besides an unclassified fragment, serves as a testimony to the continual divergent evolution of the virus with its approximate 1% per year rate of evolution, and this phenomena per se poses tremendous challenge for vaccine development against HIV-AIDS, a devastating disease that has killed 1.8 million patients in 2010. Here, we explore the interaction between HIV-1 and host genetic variation in the context of HIV-AIDS and antiretroviral therapy response.





Autor: Raghavan Sampathkumar, Elnaz Shadabi, and Ma Luo

Fuente: https://www.hindawi.com/



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