Treatment of diffuse alveolar hemorrhage secondary to lupus erythematosus with recombinant activated factor VII administered with a jet nebulizerReportar como inadecuado




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Journal of Intensive Care

, 2:47

First Online: 27 August 2014Received: 26 November 2013Accepted: 21 July 2014

Abstract

Diffuse alveolar hemorrhage DAH is a serious pulmonary complication in patients with autoimmune diseases who are undergoing chemotherapy or have had hematopoietic stem cell transplantation. The use of recombinant factor VIIa rFVIIa to treat the acute phase of DAH by endobronchial bronchoscopy has been shown to have a significant clinical impact on the survival and evolution of these patients. We report a clinical case of a patient with DAH secondary to systemic lupus erythematosus SLE who was treated with rFVIIa administered using a jet nebulizer, obtaining an adequate hemostatic effect with immediate control of DAH and a significant improvement in gas exchange.

KeywordsDiffuse alveolar hemorrhage DAH recombinant activated factor VII Systemic lupus erythematosus SLE AbbreviationsANAantinuclear antibodies

ANCAanticentromere antibodies

BALbronchoalveolar lavage

CRPC-reactive protein

CTcomputed tomography

DAHdiffuse alveolar hemorrhage

ICUintensive care unit

rFVIIarecombinant activated factor VII

SLEsystemic lupus erythematosus

TFtissue factor

TFPItissue factor pathway inhibitor

Electronic supplementary materialThe online version of this article doi:10.1186-s40560-014-0047-2 contains supplementary material, which is available to authorized users.

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Autor: Raúl Carrillo Esper - Isis EspinozadelosMonteros Estrada - Teresa de la Torre León - Agustín OmarRosales Gutiérrez - Jo

Fuente: https://link.springer.com/







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