Evaluation of reactive oxygen metabolites in patients with non-small cell lung cancer after chemotherapyReportar como inadecuado




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Multidisciplinary Respiratory Medicine

, 9:44

First Online: 29 August 2014Received: 30 March 2014Accepted: 21 July 2014

Abstract

BackgroundThe aim of this study was to evaluate the level of reactive oxygen metabolites ROMs after chemotherapy in patients with non-small cell lung cancer NSCLC and its association with response to treatment.

MethodsFifty-eight untreated NSCLC patients and twenty-three healthy subjects were selected for the study. Patients received two courses of platinum-based chemotherapy and were evaluated for oxidative stress and treatment response. As a marker of reactive oxygen species, ROMs levels were measured using the d-ROMs test.

ResultsROMs level mean ± standard deviation before chemotherapy in NSCLC patients 416 ± 135 U.CARR was significantly elevated p = 0.016 compared to normal healthy subjects 320 ± 59 U.CARR. Patients who responded to chemotherapy showed significantly decreased p = 0.014 ROMs levels after chemotherapy, whereas patients who had stable disease or progressive disease showed no change in ROMs level p = 0.387.

ConclusionsNSCLC patients had significantly elevated ROMs levels before chemotherapy compared with normal healthy subjects. Chemotherapy may suppress ROMs production in responders but not in non-responders. ROMs level may be a predictor of clinical outcome in patients receiving chemotherapy for NSCLC.

KeywordsChemotherapy Lung cancer Oxidative stress Reactive oxygen metabolites Reactive oxygen species AbbreviationsCRComplete response

NSCLCNon-small cell lung cancer

PRPartial response

PDProgressive disease

ROMReactive oxygen metabolites

SDStable disease.

Electronic supplementary materialThe online version of this article doi:10.1186-2049-6958-9-44 contains supplementary material, which is available to authorized users.

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Autor: Toru Wakabayashi - Tatsuo Kawashima - Yasuo Matsuzawa

Fuente: https://link.springer.com/







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