Serum thyroid-stimulating hormone levels are not associated with exercise capacity and lung function parameters in two population-based studiesReportar como inadecuado




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BMC Pulmonary Medicine

, 14:145

Epidemiology and public health

Abstract

BackgroundThyroid dysfunction has been described to be linked to a variety of cardiovascular morbidities. Through this pathway thyroid function might also be associated with cardiorespiratory function and exercise capacity. So far only few patient-studies with small study populations investigated the association between thyroid dysfunction and exercise capacity. Thus, the aim of our study was to investigate the association of serum thyroid-stimulating hormone TSH levels with lung function and cardiopulmonary exercise testing CPET in the general population.

MethodsData from the two independent cross-sectional population-based studies Study of Health in Pomerania SHIP and SHIP-Trend-0 were pooled. SHIP was conducted between 2002 and 2006 and SHIP-Trend-0 between 2008 and 2012. Participants were randomly selected from population registries. In total, 4206 individuals with complete data were available for the present analysis. Thyroid function was defined based on serum TSH levels. Lung function was evaluated by forced expiratory volume in 1 s and forced vital capacity. CPET was based on symptom limited exercise tests on a bicycle in a sitting position according to a modified Jones protocol. Associations of serum TSH levels with lung function and CPET parameters were analysed by multivariable quantile regression adjusted for age, sex, height, weight, use of beta blockers, smoking status, and physical activity.

ResultsSerum TSH levels, used as continuously distributed variable and categorized according to the clinical cut-offs 0.3 and 3.0 mIU-L or according to quintiles, were not consistently associated with parameters of lung function or CPET.

ConclusionsOur results suggest that thyroid dysfunction is not associated with lung function and cardiopulmonary exercise capacity in the general population.

KeywordsTSH Hyperthyroidism Hypothyroidism Exercise capacity Lung function Oxygen uptake Spirometry Population-based study Epidemiology Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-14-145 contains supplementary material, which is available to authorized users.

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Autor: Till Ittermann - Sven Gläser - Ralf Ewert - Stephan Felix - Henry Völzke - Marcus Dörr

Fuente: https://link.springer.com/



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