Potentially Biodynamic Tetraaza Macrocycles and their Manganese Complexes: Antiandrogen, Antimicrobial and PDI StudiesReport as inadecuate




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Bioinorganic Chemistry and Applications - Volume 3 2005, Issue 3-4, Pages 161-177



Department of Chemistry, University of Rajasthan, Jaipur 302 004, India

Hindu College Sonipat, 131001, India



Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fourteen to eighteen membered tetraazamacrocyclic ligands N4TTD

–N4TTD

have been synthesized bythe condensation of aliphatic diamines. H2N–CH2y–NH2 y = 2 or 3 and dicarboxylic acids, HOOC-CH2x–COOH x = 1 or 2 in the presence of condensing reagents dicyclohexylcarbodiimide DCHC and 4-dimethylaminopyridine DMAP. On reduction these macrocyclic ligands give N4TTD

-N4TTD

, which formcomplexes with manganeseII acetate. The new products with octahedral geometry have been characterizedby elemental analyses, molecular weight determinations, magnetic moment and spectral studies viz., infrared,electronic, mass and X-ray. On the basis of the spectral studies the binding sites are proposed as the nitrogenatom of the macrocycles. The formulation of the complexes as MnCH3COO2N4TTD

where n = 1 - 8has been established on the basis of chemical composition. To assess the growth inhibiting potential of theligands and their manganese II complexes biological screening have been undertaken. The testicularmorphology, testicular sperm density, sperm motility, density of cauda epididymal spermatozoa and fertilityin mating trials and biochemical parameters of reproductive organs with ligands and their correspondingcomplexes, in vivo have also been described in the this communication.





Author: Ashu Chaudhary, Anita Phor, and R. V. Singh

Source: https://www.hindawi.com/



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