The effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genesReport as inadecuate

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BMC Pulmonary Medicine

, 14:154

Epidemiology and public health


BackgroundExposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections RTIs during early infancy.

MethodsTrait anxiety levels in 440 women were assessed by the State-Trait Anxiety Inventory during late gestation. The occurrence of RTIs, including bronchiolitis, during the first year of life was assessed by parent-reported doctor diagnosis. Polymorphisms in glutathione S-transferase P-1 GSTP1, rs1695 and CD14 rs2569190 were genotyped using the TaqMan assay. Copy number variations of GSTT1 were measured by real-time polymerase chain reaction.

ResultsExposure to high levels of perinatal anxiety increased the risk of bronchiolitis in the first year of life adjusted odds ratio aOR, 1.30; 95% confidence interval CI: 1.00–1.80, in particular among children with the AG + GG genotype of GSTP1 or the GSTT1 null genotype aOR 3.36 and 2.79. In infants with the TC + CC genotype of CD14, high levels of perinatal anxiety were associated with an increased risk of upper RTI, lower RTI, and bronchiolitis aOR 2.51, 4.60, and 4.31, respectively.

ConclusionsPerinatal maternal anxiety levels affect the occurrence of bronchiolitis in offspring. The effect of perinatal anxiety on the occurrence of bronchiolitis during infancy was influenced by genetic polymorphisms in antioxidant defense and innate immunity genes.

KeywordsAnxiety Bronchiolitis CD14 Perinatal Glutathione S-transferase Polymorphism Respiratory tract infection AbbreviationsCIConfidence interval

COCOACOhort for childhood origin of asthma and allergic disease

GSTM1Glutathione S-transferase M1

GSTP1Glutathione S-transferase P1

GSTT1Glutathione S-transferase T1

LRTIsLower respiratory tract infections

PCRPolymerase chain reaction

ROSReactive oxygen species

RSVRespiratory syncytial virus

RTIRespiratory tract infection

SDStandard deviation

STAIState-Trait Anxiety Inventory

URTIsUpper respiratory tract infections.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-14-154 contains supplementary material, which is available to authorized users.

Eun Lee, Hyoung Yoon Chang contributed equally to this work.

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Author: Eun Lee - Hyoung Yoon Chang - Kyung-Sook Lee - Dong In Suh - Ho-Sung Yu - Mi-Jin Kang - In Ae Choi - Jinah Park - Kyung


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