Self-reported exercise and longitudinal outcomes in cystic fibrosis: a retrospective cohort studyReport as inadecuate




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BMC Pulmonary Medicine

, 14:159

Infectious, Rare and Idiopathic Pulmonary Diseases

Abstract

BackgroundCystic fibrosis CF is characterized by recurrent respiratory infections and progressive lung disease. Whereas exercise may contribute to preserving lung function, its benefit is difficult to ascertain given the selection bias of healthier patients being more predisposed to exercise. Our objective was to examine the role of self-reported exercise with longitudinal lung function and body mass index BMI measures in CF.

MethodsA total of 1038 subjects with CF were recruited through the U.S. CF Twin-Sibling Study. Questionnaires were used to determine exercise habits. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track outcomes.

ResultsWithin the study sample 75% of subjects self-reported regular exercise. Exercise was associated with an older age of diagnosis p = 0.002, older age at the time of ascertainment p < 0.001, and higher baseline FEV1 p = 0.001, but not CFTR genotype p = 0.64 or exocrine pancreatic function p = 0.19. In adjusted mixed models, exercise was associated with both a reduced decline in FEV1 p < 0.001 and BMI Z-score p = 0.001 for adults, but not children aged 10–17 years old.

ConclusionsIn our retrospective study, self-reported exercise was associated with improved longitudinal nutritional and pulmonary outcomes in cystic fibrosis for adults. Although prospective studies are needed to confirm these associations, programs to promote regular exercise among individuals with cystic fibrosis would be beneficial.

KeywordsCystic fibrosis Lung function FEV1 Body mass index Exercise AbbreviationsBMIBody mass index

CFCystic fibrosis

FEV1Forced expiratory volume in 1 second.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2466-14-159 contains supplementary material, which is available to authorized users.

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Author: Joseph M Collaco - Scott M Blackman - Karen S Raraigh - Christopher B Morrow - Garry R Cutting - Shruti M Paranjape

Source: https://link.springer.com/







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